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API Name |
CAS No |
Structure |
Status |
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Brigatinib |
1197953-54-0 |
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Commercial |
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Brigatinib：
Molecular weight: 584.09
Chemical formula: C29H39ClN7O2P
CAS number: 1197953-54-0
Appearance：White to light yellow
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Brigatinib is a anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma enzyme positive metastatic non-small cell lung cancer.
Brigitanib inhibits the proliferation and in vitro survival of cells expressing the fusion protein EML4-ALK and 17 anti Crizotinib ALK mutants. Its function extends to cells expressing EGFR deficiency, ROS1-L2026M, FLT3-F691L, and FLT3-D835Y. In the mouse EML4-ALK xenograft model, brigatinib exhibits dose-dependent inhibitory effects on tumor growth, tumor burden, and prolonged survival.
Brigatinib (AP-26113, AP26113), also known as brigatinib, is an effective ALK selective inhibitor with an IC50 of 0.6 nM; It is also a ROS1 inhibitor with an IC50 of 0.9 nM. Brigatinib is a new generation tyrosine kinase inhibitor commonly used in combination with EGFR for the treatment of cancer, and has shown promising therapeutic potential for lung cancer in clinical trials.
English Synonym:Brigatinib, AP-26113, AP26113
Protein Tyrosine Kinase--ALK
CAS Number:1197953-54-0
Molecular formula :C29H39ClN7O2P
Purity：≥98%
Solubility：Dissolved in DMSO
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